Locked-in syndrome (LIS) is a rare and devastating neurological condition characterized by complete paralysis of nearly all voluntary muscles, with the exception of vertical eye movements and blinking, while consciousness and cognitive abilities remain fully intact. It typically results from severe damage to the brainstem, most commonly due to a stroke (pontine hemorrhage or infarct), but can also be caused by trauma, infection, tumors, or certain neurological disorders like severe Guillain-Barré syndrome.
Patients with LIS are essentially “locked” within their own bodies, unable to speak, move their limbs or trunk, or make facial expressions, but they can hear, see, think, and understand everything around them. Their only means of communication is usually through intentional vertical eye movements or blinks.
The profound physical limitations in LIS necessitate a highly specialized and advanced physiotherapy approach, focusing on maintaining physiological function, preventing complications, optimizing residual abilities, and facilitating communication and quality of life.
Advanced physiotherapy for LIS is a crucial component of a multidisciplinary rehabilitation team (including neurologists, speech therapists, occupational therapists, respiratory therapists, nurses, and psychologists).
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