Progressive Supranuclear Palsy: Symptoms, Treatment & Care post thumbnail image

Best Progressive Supranuclear Palsy Treatment in Delhi

What is Progressive Supranuclear Palsy ?

Progressive Supranuclear Palsy (PSP) is a rare and complex neurological condition that progressively damages brain cells, leading to problems with movement, balance, vision, speech, and swallowing. It is considered an “atypical parkinsonism” because some of its symptoms can resemble Parkinson’s disease, but it has distinct features and typically progresses more rapidly.

What causes PSP?

The exact cause of PSP is unknown. However, it is characterized by the abnormal accumulation of a protein called tau in specific areas of the brain, particularly the brainstem, basal ganglia, and cerebral cortex. While tau is naturally present in the brain, in PSP, it forms harmful clumps that lead to the damage and death of nerve cells. This cell damage disrupts the brain’s ability to control various functions. Rarely, PSP can have a genetic link, but it is generally not considered an inherited condition. Most cases develop in people over the age of 60.

Symptoms of PSP

Symptoms of PSP usually worsen gradually over time and can vary significantly between individuals. Early symptoms can sometimes be mistaken for normal aging or other conditions. Common symptoms include:

  • Balance and Mobility Problems: This is often one of the first and most prominent symptoms, leading to frequent and unexplained falls, especially backward. People with PSP may experience muscle stiffness (axial rigidity), particularly in the neck and trunk, and have an unsteady or clumsy gait.
  • Eye Movement Abnormalities (Supranuclear Gaze Palsy): This is a hallmark symptom of PSP. Individuals may have difficulty moving their eyes, especially up and down, and later from side to side. This can lead to blurred or double vision, difficulty focusing, and a tendency to move the head rather than the eyes to look in different directions. Eyelid problems like reduced blinking, involuntary blinking (blepharospasm), or difficulty opening the eyes are also common.
  • Speech and Swallowing Difficulties (Dysarthria and Dysphagia): Speech may become slow, quiet, or slurred. Swallowing can become increasingly difficult, leading to choking and a higher risk of aspiration pneumonia (a chest infection caused by food or liquid entering the lungs).
  • Cognitive and Behavioral Changes: These can include slowness of thought, mild-to-moderate memory problems, difficulty with reasoning and decision-making, impulsivity, poor judgment, irritability, apathy (lack of interest), and sometimes unexplained emotional outbursts (crying or laughing).
  • Other Symptoms: Muscle stiffness, tremors (though less common and prominent than in Parkinson’s), a fixed or startled facial expression, dizziness, and sleep disturbances can also occur.
Diagnosis:

There is no single diagnostic test for PSP. Diagnosis is primarily based on a thorough medical history, physical examination, and neurological assessment of symptoms. Doctors may also use MRI or other imaging tests to look for brain shrinkage in affected areas and to rule out other conditions. The lack of response to typical Parkinson’s medications can also be a clue.

Treatment:

Currently, there is no cure for PSP, and treatments focus on managing symptoms and improving quality of life.

  • Medications:
    • Parkinson’s disease medications (e.g., levodopa): While not a cure, some people, especially in the early stages, may experience temporary and limited improvement in balance and stiffness.
    • Antidepressants: Can help manage depression and sometimes improve balance or sleep.
    • Botox injections: May be used to treat eyelid spasms.
  • Therapies:
    • Physical therapy: Helps with balance, posture, muscle strengthening, and fall prevention. It may include gait and balance training.
    • Occupational therapy: Focuses on adapting daily tasks and providing equipment to maintain independence.
    • Speech and language therapy: Addresses speech clarity and swallowing difficulties, offering techniques and strategies to improve communication and safe eating.

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