Progressive Supranuclear Palsy (PSP) is a rare and complex neurological condition that progressively damages brain cells, leading to problems with movement, balance, vision, speech, and swallowing. It is considered an “atypical parkinsonism” because some of its symptoms can resemble Parkinson’s disease, but it has distinct features and typically progresses more rapidly.
The exact cause of PSP is unknown. However, it is characterized by the abnormal accumulation of a protein called tau in specific areas of the brain, particularly the brainstem, basal ganglia, and cerebral cortex. While tau is naturally present in the brain, in PSP, it forms harmful clumps that lead to the damage and death of nerve cells. This cell damage disrupts the brain’s ability to control various functions. Rarely, PSP can have a genetic link, but it is generally not considered an inherited condition. Most cases develop in people over the age of 60.
Symptoms of PSP usually worsen gradually over time and can vary significantly between individuals. Early symptoms can sometimes be mistaken for normal aging or other conditions. Common symptoms include:
There is no single diagnostic test for PSP. Diagnosis is primarily based on a thorough medical history, physical examination, and neurological assessment of symptoms. Doctors may also use MRI or other imaging tests to look for brain shrinkage in affected areas and to rule out other conditions. The lack of response to typical Parkinson’s medications can also be a clue.
Treatment:
Currently, there is no cure for PSP, and treatments focus on managing symptoms and improving quality of life.
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