Reflex Sympathetic Dystrophy (RSD) is an older term for what is now more commonly known as Complex Regional Pain Syndrome (CRPS). CRPS is a chronic, debilitating pain condition that typically affects an arm, leg, hand, or foot, often after an injury, surgery, stroke, or heart attack. The pain is usually disproportionate to the initial injury and can worsen over time.
The underlying mechanism is thought to involve a complex interplay of the sympathetic nervous system (which regulates blood flow, sweating, etc.), the immune system (leading to inflammation), and the somatosensory system (involved in processing pain). This leads to abnormal signals being sent to the brain, resulting in the characteristic symptoms.
The symptoms of CRPS are highly variable and can change over time. They typically affect the injured limb but can sometimes spread to other body parts.
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