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Best Transverse Myelitis Treatment in Delhi

What is Trigeminal Neuralgia ?

Transverse Myelitis (TM) is a rare neurological disorder characterized by inflammation of both sides of one section of the spinal cord. This inflammation can damage myelin, the protective insulating material covering nerve cell fibers, disrupting the messages that the spinal cord nerves send throughout the body. This interruption can lead to a range of symptoms, including pain, muscle weakness, paralysis, sensory problems, and bladder and bowel dysfunction.

Causes

The exact cause of transverse myelitis is often unknown, and in many cases, it is considered “idiopathic.”

  • Autoimmune reactions: The immune system mistakenly attacks the body’s own tissues, specifically the myelin in the spinal cord. TM can be the first sign of an autoimmune or immune-mediated disease like:-
    • Multiple Sclerosis (MS): A disorder where the immune system attacks myelin in the brain and spinal cord. TM can be an initial symptom or a relapse of MS.
    • Neuromyelitis Optica Spectrum Disorder (NMOSD): A condition that causes inflammation and myelin loss around the spinal cord and the optic nerve.
    • Myelin Oligodendrocyte Glycoprotein (MOG) antibody-associated disease (MOGAD): A newly recognized autoimmune condition affecting myelin.
    • Lupus (Systemic Lupus Erythematosus – SLE)
    • Sarcoidosis
  • Infections: TM can occur after viral, bacterial, or fungal infections, either directly or as a post-infectious immune response. Examples include:
    • Viruses: Herpes viruses (like varicella-zoster, cytomegalovirus, Epstein-Barr), influenza, HIV.
    • Bacteria: Mycoplasma pneumoniae, Lyme disease, syphilis.
  • Other inflammatory disorders:
  • Vaccinations: In rare cases, TM has been reported to occur after certain vaccinations.
  • Certain cancers: Some cancers can trigger an unusual immune response that leads to TM.
Symptoms

Symptoms of transverse myelitis typically develop over a few hours to a few days, sometimes progressing gradually over several weeks. They usually affect both sides of the body below the inflamed section of the spinal cord, though sometimes only one side is affected. Common symptoms include:-

  • Weakness in arms or legs: This can range from a heavy feeling to severe weakness or complete paralysis (often starting in the legs and sometimes affecting the arms if the upper spinal cord is involved).
  • Pain: Often starts as lower back pain or sharp, shooting pain that radiates down the legs or arms or around the torso. A “banding” or “girdle-like” sensation around the trunk is also common.
  • Sensory Problems :-
    • Numbness, tingling, prickling, burning, or cold sensations.
    • Heightened sensitivity to touch or temperature.
    • Loss of sensation in affected areas.
  • Bowel and bladder dysfunction:
    • Increased urinary urgency or frequency.
    • Difficulty holding urine (incontinence) or inability to urinate (retention).
    • Constipation or difficulty with bowel control.
  • Sexual dysfunction.
  • Muscle spasms and spasticity.
  • Fatigue.
  • Depression and anxiety.

The specific symptoms and their severity depend on which part of the spinal cord is inflamed. Inflammation in the neck (cervical spine) can cause symptoms from the neck down, while inflammation in the chest (thoracic spine) typically affects the trunk and legs.

Diagnosis

Diagnosing transverse myelitis involves a combination of:-

  • Medical history and physical exam: Assessing symptoms and neurological function.
  • Magnetic Resonance Imaging (MRI): Of the spinal cord and sometimes the brain, to detect inflammation, swelling, or lesions and rule out other conditions like spinal cord compression.
  • Lumbar puncture (spinal tap): To analyze cerebrospinal fluid (CSF) for signs of inflammation (e.g., elevated white blood cell count, increased protein) and to test for specific antibodies or infections.
  • Blood tests: To check for signs of infection, inflammation, or autoimmune markers.

Treatment

The primary goals of transverse myelitis treatment are to reduce inflammation, manage symptoms, and prevent complications.

    • Physical therapy: Crucial for regaining strength, coordination, balance, and mobility; may involve exercises, assistive devices (wheelchairs, braces).
    • Occupational therapy: Helps individuals learn new ways to perform daily activities.
    • Psychotherapy: To address anxiety, depression, and other emotional challenges.

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